A dividing matter: Drp1/Dnm1-independent mitophagy
نویسنده
چکیده
Whether or not mitophagy depends on prior mitochondrial fragmentation by the canonical mitochondrial division machinery is controversial. In this issue, Yamashita et al. (2016. J. Cell Biol. https://doi.org/10.1083/jcb.201605093) report that mitochondrial fragments start to bud and divide from mitochondrial tubules when in tight association with forming autophagosomes, but independently of the mitochondrial division factor Drp1/Dnm1.
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Mitochondrial division occurs concurrently with autophagosome formation but independently of Drp1 during mitophagy
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